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KMID : 1123920160300040266
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Korean Journal of Oriental Physiology and Pathology
2016 Volume.30 No. 4 p.266 ~ p.273
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Study of Anti-inflammatory Effect of Ohmae-hwan Water Extract
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Kim Young-Hwan
Song Ae-Jin
Sung Sun-Heui
Kwon Dong-Yeul
Jung Myung-su
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Abstract
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Ohmae-hwan has been used to treat the symptoms of loose stools mixed with blood accompanied by abdominal pain due to heat dysentery in Korean medicine. However, its mechanism of action on inflammatory disease using macrophages was not known. The author was to find out about the influence of Ohmae-hwan water extract on expressions of NO, cytokine IL-6 and TNF-α in LPS-stimulated RAW 264.7 cell, on expressions of mRNA of iNOS, IL-6 and COX-2 and on suppression of expressions of protein of iNOS and COX-2, and was to find out about the mechanism. As a result of the study, it was found that Ohmae-hwan suppressed generation of NO activated by LPS depending on its concentrations, suppressed expressions of cytokine IL-6, and TNF-α and suppressed expressions of mRNA of iNOS, IL-6, and COX-2 and suppressed expressions of protein of iNOS, COX-2. Considering the above results, it can be known that Ohmae-hwan water extract has anti-inflammatory effect against inflammatory response mediated by macrophages by suppressing generation of NO, TNF-α, and IL-6 and expressions of iNOS, COX-2 as it acts on macrophages.
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KEYWORD
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Ohmae-hwan, Anti-inflammatory Effect, RAW 264.7 cell
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